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M9480519.TXT
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1994-08-20
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Document 0519
DOCN M9480519
TI Bacille Calmette-Guerin immunization in normal healthy adults.
DT 9410
AU Brewer MA; Edwards KM; Palmer PS; Hinson HP; Department of Pediatrics,
Vanderbilt University School of; Medicine, Nashville, Tennessee.
SO J Infect Dis. 1994 Aug;170(2):476-9. Unique Identifier : AIDSLINE
MED/94308625
AB Bacille Calmette-Guerin (BCG) vaccine was administered to 20 purified
protein derivative (PPD) skin test-negative and human immunodeficiency
virus serology-negative, healthy adults 18-65 years old. Local adverse
reactions were monitored and intermediate-strength PPD skin test
responses were evaluated 2 months and 1 year after vaccination. All
vaccinees developed erythema, induration, and tenderness at the
vaccination site. Muscular soreness was reported by 15 subjects, local
ulceration with drainage by 14, and tender regional adenopathy by 2. BCG
organisms were isolated from the ulcer of the only vaccinee who was
cultured. PPD skin tests revealed induration in all subjects. Normal
healthy adults at risk of occupational exposure to tuberculosis and
considering BCG immunization should be fully informed about the local
reactions seen after BCG administration and the high rate of persistent
PPD skin test responses. Since viable organisms can be recovered from
ulcer drainage, vaccination sites should be covered to reduce nosocomial
transmission of the vaccine strain.
DE Adult *BCG Vaccine/ADVERSE EFFECTS/IMMUNOLOGY Female Human Male
Middle Age Mycobacterium bovis/ISOLATION & PURIF Prospective Studies
Skin Diseases/MICROBIOLOGY Support, Non-U.S. Gov't Support, U.S.
Gov't, P.H.S. Tuberculin Test Ulcer/MICROBIOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).